个人简介
李志超，博士，博士生导师，教授（2000.9 ）。中国病理生理学会(国家一级学会)常务理事，国家自然科学基金二审评委。承担国家自然科学基金5 项。发表论文130余篇，其中SCI论著45篇，主编出版专著及光盘4 部，副主编教材3部，参编教材18部。已培养博、硕士研究生31人。
承担的科研项目
2017/01-2020/12 ROS/HIF-1α/Skp2信号通路在低氧性平滑肌细胞增殖反应阈形成及血管重构中的作用及机制研究 国家自然科学基金 主持 在研
2015/01-2018/12 自噬-凋亡在低氧性肺动脉高压自然逆转中的作用及分子机制研究 国家自然科学基金 主持 结题
2013/01-2016/12 肺泡上皮细胞氧脱适应在低氧性肺动脉高压中的作用及分子机 国家自然科学基金 主持 结题
2008/01-2010/12 可控型NF-B反义RNA和IB重组载体的构建及其防治急性肺损伤的研究 国家自然科学基 主持 结题
主要研究成果
1. Luo Ying , Zhang Bo, Xu Dun-Quan, Liu Yi, M Dong ing-Qing, ZhaoPeng-Tao, Li Zhi-Chao. Protective effect of bicyclol on lipopolysaccharide -induced acute lung injury in mice. Pulmonary Pharmacology and Therapeutics. 2011;24 (1) 240~246.
2． Xu M, Cao F, Liu L, Zhang B, Wang Y, Dong H, Cui Y, Dong M, Xu D, Liu Y, Zhao P, Niu W, Li Z. Tanshinone IIA-induced Attenuation of Lung Injury in Endotoxemic Mice is Associated with Reduction of HIF-1{alpha} Expression. Am J Respir Cell Mol Biol. 2011;45(5):1028-1035
3. Liu Y, Liu M, Niu W, Luo Y, Zhang B, Li Z. Phenotype and differentiation of bone marrow-derived smooth muscle progenitor cells. Clin Exp Pharmacol Physiol. 2011 38(9): 586–591.
4. Zhang Bo, Liu Zhong-Yang, Li Yan-Yan, Luo Ying, Liu Man-Ling, Dong Hai-Ying, Wang Yan-Xia, Liu Yi, Zhao Peng-Tao, Jin Fa-Guang, Li Zhi-Chao. Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharmac Sci , 2011；44 (10) 573–579.
5. Zhang B, Luo Y, Liu ML, Wang J, Xu DQ, Dong MQ, Liu Y, Xu M, Dong HY, Zhao PT, Gao YQ, Li ZC. Macrophage migration inhibitory factor contributes to hypoxic pulmonary vasoconstriction in rats. Microvasc Res. 2012;83 (1) : 205–212.
6. Zhang Bo, Shen Min, Xu Min, Liu Li-Li, Luo Ying, Xu Dun-Quan, Wang Yan-Xia, Liu Man-Ling, Liu Yi, Dong Hai-Ying, Zhao Peng-Tao and Li Zhi-Chao. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators Inflamm. 2012; ID 840737, doi:10.1155/2012/840737
7. Liu Man-Ling ,1, Dong Hai-Ying ,1, Zhang Bo ,1, Zheng Wan-Song, Zhao Peng-Tao , Liu Yi , Niu Wen , Xu Dun-Quan, Li Zhi-Chao.Insulin reduces LPS-induced lethality and lung injury in rats. Pulmonary Pharmacology & Therapeutics 2012;25 (6)：472~477.
8. Dong Haiying, Ji Zhenyu , Liu Manling, Wang Yanxia, Bai Xiao , Wang Ting , Liu Zidong, Wu Yousheng, Zhang Bo, Luo Ying, Li Zhichao, Dong Mingqing. Functional expression of ERG1 potassium channels in rat alveolar macrophages. J Mol Hist 2013；44(1):117–124
9. Shi Yun, Zhang Bo, Chen Xiang-Jun, Xu Dun-Quan, Wang Yan-Xia, Dong Hai-Ying, Ma Shi-Rong, Sun Ri-He, Hui Yan-Ping, Li Zhi-Chao Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of Angiotensin-Converting Enzyme 2. Eur J Pharmac Sci 2013; 48(4-5):819–824.
10. Luo Y, Xu DQ, Dong HY, Zhang B, Liu Y, Niu W, Dong MQ, Li ZC. Tanshinone IIA Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via Akt/Skp2/p27-Associated Pathway. PLoS One. 2013；8(2):e56774.
11. Xu Dunquan *, Niu Wen *, Luo Ying *, Zhang Bo, Liu Manling，Dong Haiying, Liu*Yi, Li Zhichao. Endogenous Estrogen Attenuates Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Vasoconstriction and Pulmonary Arterial Smooth Muscle Cells Proliferation. Int. J. Med. Sci. 2013; 10(6):771-781. doi: 10.7150/ijms.5906..
12. Chen XJ, Zhang B, Hou SJ, Shi Y, Xu DQ, Wang YX, Liu ML, Dong HY, Sun RH, Bao ND, Jin FG, Li ZC. Osthole improves acute lung injury in mice by up-regulating Nrf-2/thioredoxin 1. Respir Physiol Neurobiol. 2013; 188(2): 214-222 .
13. Xu Dun-quan , Gao Cao,#, Niu Wen, Li Yan, Wang Yan-xia, Gao Chang-jun, Ding Qian, Yao Li-nong, ChaiI Wei, *, Li Zhi-chao, Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats .Acta Pharmacologica Sinica 2013: 1–11
14. Dong HY, Xu M,Ji ZY,Wang YX,Dong MQ,Liu ML,Xu DQ,Zhao PT, Liu Y,Luo Y,Niu W,Zhang B,Ye J,Li ZC. Leptin Attenuates Lipopolysaccharide or Oleic Acid-Induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2013;49(6):1057-1063..
15.Zhang Bo，Niu Wen, Xu Dunquan, Li Yanyan,Liu Manling, Wang Yanxia , Luo Ying, Zhao Pengtao,Liu Yi, Dong Mingqing, Sun Rihe,Dong Haiying,Li Zhichao. Oxymatrine prevents hypoxia and monocrotaline-induced pulmonary hypertension in rats. Free Radical Biolo Med. 2014；69(1)：198–207.
16. Liu Manlin; Wang Yanxia ; Zheng Lianhe ; Zheng Wansong ; Dong Kai ; Chen Shuai ; Zhang Bo ; Li Zhichao*. Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α. Respiratory Physiology & Neurobiology 2014 (201 ) 38–46
17. Luo Y, Dong HY, Zhang B, Feng Z, Liu Y, Gao YQ, Dong MQ*, Li ZC*. miR-29a-3p Attenuates Hypoxic Pulmonary Hypertension by Inhibiting Pulmonary Adventitial Fibroblast Activation. Hypertension. 2015;65(2):414-420 .
18. Wang YX#. , Liu ML#., Zhang B, Fu EQ. , Li Z-C*. Fasudil alleviated hypoxia-induced pulmonary hypertension by stabilizing the expression of angiotensin-(1-7) in rats. European Review for Medical and Pharmacological Sciences. 2016; 20（15）: 3304-3312
19. Xu Dunquan, Li Yan, Zhang Bo, Wang Yanxia, Liu Yi, Luo Ying, Niu Wen, Dong Mingqing, Liu Manling, Dong Haiying, Zhao Pengtao, Li Zhichao*. Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats. Int J Med Sci 2016; 13(12): 942-954.
20. Chen J, Wang YX, Dong MQ, Zhang B, Luo Y, Niu W, Li ZC*. Reoxygenation Reverses Hypoxic Pulmonary Arterial Remodeling by Inducing Smooth Muscle Cell Apoptosis via Reactive Oxygen Species-Mediated Mitochondrial Dysfunction. J Am Heart Assoc. 2017 6:e005602.
21. Dong HY#, Cui Y#, Zhang B#*, Luo Y, Wang YX, Dong MQ, Liu ML, Zhao PT, Niu W, Li ZC*. Automatic regulation of NF-κB by pHSP70/IκBαm to prevent acute lung injury in mice. Arch Biochem Biophys. 2017; 634 : 47~56
22. Zhang Bo#*,Niu Wen#,Dong Hai Ying,Liu Man Ling,Luo Ying,Li Zhi Chao*.Hypoxia induces endothelial mesenchymal transition in pulmonary vascular remodeling. Int J Mol Med. 2018 Mar 22. doi: 10.3892/ijmm.2018.3584.
23. Wang Yanxia #, Wu Huajie#, Niu Wen, Chen Jian, Liu Manlin, Sun,Xin *, LI Zhichaoi* Tanshinone IIA attenuates paraquat induced acute lung injury by modulating angiotensin converting enzyme 2/angiotensin (1 7) in rats. Mol Med Report.2018.9281: 2955-2962.
获得的教学和科研表彰
2001．11 二氢吡啶类钙拮抗剂的构效关系及药理作用研究 陕西省科技进步奖二等奖
2002．12 高海拔地区创伤感染急性肺损伤/急性呼吸窘迫综合征诊断标准与防治研究 军队科技进步一等奖
2012．12 心房钠尿肽、丹参酮IIA对实验性急性肺损伤的防治作用及机制研究 新疆自治区科技进步奖一等奖
2015．01 ALI/ARDS发病的关键机制及救治研究 陕西省科技进步奖一等奖
2001年获军队育才银奖
